Who Is Bryan Johnson?
Bryan Johnson is the founder of OS Fund, a venture fund backing scientists working on breakthroughs in biology, and Kernel, a company building non-invasive brain-computer interfaces. In 2013, he sold his payment company Braintree (which owned Venmo) to PayPal for $800 million.
Since 2021, Johnson has become the world's most visible longevity self-experimenter through his Blueprint protocol — a rigorous, data-driven attempt to minimize his biological age. He employs a team of 30 medical professionals who conduct daily biomarker testing, and he has publicly shared all measurements, protocols, and costs.
Key Contributions to Longevity Science
Blueprint Protocol (Open Source) Johnson's Blueprint is now fully public at blueprint.bryanjohnson.com. It covers:
- Precise nutrition (vegan, calorie-restricted, anti-inflammatory)
- Sleep optimization (9pm bedtime, 8.5hr window, temperature-controlled mattress)
- Exercise (1hr/day, Zone 2 + resistance)
- 111 supplements with specific dosing and timing
Measured Results (as of 2024)
- Epigenetic age: ~5 years below chronological age (46)
- Heart age: measured at 37
- Lung function: top 1.5% for his age group
- Inflammation (hsCRP): near zero
Don't Die Philosophy Johnson has expanded Blueprint into a broader philosophy he calls "Don't Die" — the idea that death-by-aging is a solvable engineering problem, and that making the decision to treat your body with the same rigor you'd apply to a high-performance machine is the first step.
Why Follow Him
If you want the most data-dense, protocol-driven approach to longevity currently available, Bryan Johnson's work is the most rigorous public experiment in existence. His openness about failures and measurement methodology makes him uniquely useful — even if you'd never follow his exact protocol.